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These secondary endpoints are particularly valuable for researchers studying the broader metabolic impact of triple receptor agonism, as they reflect changes that extend well beyond what the scale measures

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More recently, a multi-layered and single-cell transcriptome analysis of Schwann cells and the full sciatic nerve revealed that cortistatin and its receptors are expressed not only in Schwann cells but also in other cells of the sciatic nerve, including pericytes, epineurial, endothelial, and immune cells [86]